Toward Sustainable Trifluoromethylation Reactions: Sodium Triflinate under the Spotlight

Dedicated to Dr. Bernard Langlois

Abstract

Direct trifluoromethylation of organic molecules is of upmost importance in medicinal chemistry and agrochemical research. However, finding sustainable reaction conditions should be a priority for chemists to improve the applicability of their research. Herein, we highlight recent advances in transition-metal-free and photochemical activation of sodium triflinate, a commercially available and easy-to-handle source of CF₃ radical.

1. Introduction

2. Transition-Metal-Free Activation of Sodium Triflinate

3. Photochemical Activation of Sodium Triflinate

4. Conclusions and Outlook

Key words

sodium triflinate - Langlois reagent - peroxides - hypervalent iodine - photoredox catalysis - visible light

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