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Synlett 2017; 28(01): 19-23
DOI: 10.1055/s-0036-1588643
DOI: 10.1055/s-0036-1588643
synpacts
Toward Sustainable Trifluoromethylation Reactions: Sodium Triflinate under the Spotlight
Weitere Informationen
Publikationsverlauf
Received: 23. September 2016
Accepted after revision: 12. Oktober 2016
Publikationsdatum:
07. November 2016 (online)
![](https://www.thieme-connect.de/media/synlett/201701/lookinside/thumbnails/st-2016-p0633-sp_10-1055_s-0036-1588643-1.jpg)
Dedicated to Dr. Bernard Langlois
Abstract
Direct trifluoromethylation of organic molecules is of upmost importance in medicinal chemistry and agrochemical research. However, finding sustainable reaction conditions should be a priority for chemists to improve the applicability of their research. Herein, we highlight recent advances in transition-metal-free and photochemical activation of sodium triflinate, a commercially available and easy-to-handle source of CF3 radical.
1. Introduction
2. Transition-Metal-Free Activation of Sodium Triflinate
3. Photochemical Activation of Sodium Triflinate
4. Conclusions and Outlook
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For a pioneering example, see:
For a hydrotrifluoromethylation reaction with Umemoto reagent, see: