Synlett 2018; 29(10): 1351-1357
DOI: 10.1055/s-0036-1591563
letter
© Georg Thieme Verlag Stuttgart · New York

First Total Synthesis of Oxirapentyn D, a Highly Oxidized Chromene Natural Product

Takahiro Sakai
Department of Chemistry, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro-ku, Tokyo 152-8551, Japan   Email: kohmori@chem.titech.ac.jp
,
Keisuke Suzuki
Department of Chemistry, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro-ku, Tokyo 152-8551, Japan   Email: kohmori@chem.titech.ac.jp
,
Department of Chemistry, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro-ku, Tokyo 152-8551, Japan   Email: kohmori@chem.titech.ac.jp
› Author Affiliations

This work was supported by a Grant-in-Aid for Scientific Research (S) (No. 16H06351) from the Japan Society for the Promotion of Science (JSPS).
Further Information

Publication History

Received: 08 February 2018

Accepted after revision: 12 March 2018

Publication Date:
13 April 2018 (online)


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Dedicated to Prof. Victor Snieckus on occasion of his 80th birthday

Abstract

The first total synthesis of oxirapentyn D from myo-inositol has been achieved by utilizing chelation-directed bridgehead lithiation of a hydrazone derivative.

Supporting Information