C–S Bond Alkynylation of Diaryl Sulfoxides with Terminal Alkynes by Means of a Palladium–NHC Catalyst

Published as part of the Cluster C–O Activation

Abstract

Sonogashira–Hagihara-type alkynylation of diaryl sulfoxides with unactivated terminal alkynes has been developed. With a combination of a palladium–NHC catalyst and LiOtBu as a base, a series of diaryl sulfoxides were converted into the alkynylated products via C–S bond cleavage.

Key words

C–S bond alkynylation - palladium catalyst - aryl sulfoxide - alkyne

• References and Notes

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Alkanesulfenate anions are less stable than arenesulfenate anions:
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