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Synlett 2018; 29(08): 1033-1036
DOI: 10.1055/s-0036-1591765
DOI: 10.1055/s-0036-1591765
letter
Ruthenium-Catalyzed Ortho C(sp2)–H Amidation of Benzaldehydes with Organic Azides
O.K.R. thanks the Wuhan University of Technology for financial support. Also, O.K.R. thanks the University of Montana for support.Further Information
Publication History
Received: 20 November 2017
Accepted after revision: 29 January 2018
Publication Date:
16 February 2018 (online)
Abstract
A ruthenium-catalyzed functionalization of benzaldehyde substrate with organic azides promoted by various transient directing groups has been developed. In this approach, C–H amination is achieved via a transient aldimine intermediate in good to excellent yields.
Key words
C–H functionalization - directing groups - C–H activation - ruthenium catalysis - amidationSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1591765.
- Supporting Information
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For leading reviews, see:
For selected examples, see:
For selected examples, see:
For selected examples of C(sp2)−H functionalizations of benzaldehyde: