Download PDF
Synfacts 2018; 14(05): 0455
DOI: 10.1055/s-0037-1609498
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of GDC-0810

Contributor(s):
Philip Kocienski
Further Information

Publication History

Publication Date:
17 April 2018 (online)

    Permissions and Reprints

Key words

GDC-0810 - selective estrogen receptor degrader - diastereoselective addition - Grignard reagent - Felkin–Anh model - asynchronous concerted E1 elimination - tetrasubstituted alkene