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Synfacts 2018; 14(05): 0455
DOI: 10.1055/s-0037-1609498
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of GDC-0810

Rezensent(en):
Philip Kocienski
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Publikationsverlauf

Publikationsdatum:
17. April 2018 (online)

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Key words

GDC-0810 - selective estrogen receptor degrader - diastereoselective addition - Grignard reagent - Felkin–Anh model - asynchronous concerted E1 elimination - tetrasubstituted alkene