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Synlett 2019; 30(09): 1003-1007
DOI: 10.1055/s-0037-1610699
DOI: 10.1055/s-0037-1610699
synpacts
Potassium Alkoxide/Disilane-Mediated Dehalogenative Deuteration
We thank the National Natural Science Foundation of China (21602160 and 21772148), Wuhan University (2042018kf0017), the Fundamental Research Funds for the Central Universities and the National Program for 1000 Young Talents of China for financial support of this research.Further Information
Publication History
Received: 27 January 2019
Accepted after revision: 18 February 2019
Publication Date:
19 March 2019 (online)
Abstract
Deuterated compounds are of great importance in chemistry and pharmaceuticals. Reductive dehalogenation is one of the most useful methods to incorporate deuterium into molecules. This article briefly discusses the historical development of dehalogenative deuteration reactions that involve transition-metal catalysis, radical halogen abstraction, alkali-metal reductive deuteration, and the recently developed potassium methoxide/hexamethyldisilane-mediated dehalogenation of aryl halides.
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