Ionic Competition and ⁶⁷Ga in Vivo Accumulation

Es wurde die Wirkung verschiedener Zitrate trivalenter Kationen auf die ⁶⁷Ga-Zitrat-Speicherung von Tumortieren untersucht. Eine Beziehung zwischen der Ionengröße des gleichzeitig injizierten Kations und der Hemmung der ⁶⁷Ga-Speicherung weist darauf hin, daß die Eigenschaften des Kations (Ionenradius und elektrische Ladung) die wichtigste Rolle in der Speicherung der Radioaktivität spielen. Die offenbare Übereinstimmung dieses Phänomens mit der Hypothese des isomorphen Ersatzes wird diskutiert.

The effect of several citrates of trivalent cations on ⁶⁷Ga citrate uptake by tumor-bearing animals has been studied. A relationship between the ionic size of the simultaneously injected cation and the ⁶⁷Ga uptake inhibition indicates that the cation characteristics (ionic radius and electrical charge) seem to play the most important role in this radioactivity accumulation. The apparent agreement of this phenomenon with the isomorphous replacement hypothesis is discussed.

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