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Nuklearmedizin 1982; 21(03): 114-116
DOI: 10.1055/s-0037-1620562
Originalarbeiten – Original Articles
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Ionic Competition and 67Ga in Vivo Accumulation

Ionenkompetition und Speicherung von 67Ga in Vivo
L. J. Anghileri
1   From the Nuclear Medicine Service and Biophysics Laboratory, Faculty of Medicine B, University of Nancy, France
,
P. Thuvenot
1   From the Nuclear Medicine Service and Biophysics Laboratory, Faculty of Medicine B, University of Nancy, France
,
F. Brunotte
1   From the Nuclear Medicine Service and Biophysics Laboratory, Faculty of Medicine B, University of Nancy, France
,
C. Marchai
1   From the Nuclear Medicine Service and Biophysics Laboratory, Faculty of Medicine B, University of Nancy, France
,
J. Robert
1   From the Nuclear Medicine Service and Biophysics Laboratory, Faculty of Medicine B, University of Nancy, France
› Author Affiliations
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Publication History

Received: 23 April 1982

Publication Date:
10 January 2018 (online)

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Es wurde die Wirkung verschiedener Zitrate trivalenter Kationen auf die 67Ga-Zitrat-Speicherung von Tumortieren untersucht. Eine Beziehung zwischen der Ionengröße des gleichzeitig injizierten Kations und der Hemmung der 67Ga-Speicherung weist darauf hin, daß die Eigenschaften des Kations (Ionenradius und elektrische Ladung) die wichtigste Rolle in der Speicherung der Radioaktivität spielen. Die offenbare Übereinstimmung dieses Phänomens mit der Hypothese des isomorphen Ersatzes wird diskutiert.

The effect of several citrates of trivalent cations on 67Ga citrate uptake by tumor-bearing animals has been studied. A relationship between the ionic size of the simultaneously injected cation and the 67Ga uptake inhibition indicates that the cation characteristics (ionic radius and electrical charge) seem to play the most important role in this radioactivity accumulation. The apparent agreement of this phenomenon with the isomorphous replacement hypothesis is discussed.

 

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