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Thromb Haemost 1994; 72(04): 551-556
DOI: 10.1055/s-0038-1648913
Original Article
Schattauer GmbH Stuttgart

Antithrombin III: Associations with Age, Race, Sex and Cardiovascular Disease Risk Factors

Maureen G Conlan
1   The Atherosclerosis Risk in Communities (ARIC) Study Investigators From the University of Texas Medical School, Division of Hematology-Oncology, Houston, TX, USA
,
Aaron R Folsom
2   The Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN, USA
,
Andrea Finch
1   The Atherosclerosis Risk in Communities (ARIC) Study Investigators From the University of Texas Medical School, Division of Hematology-Oncology, Houston, TX, USA
,
C E Davis
3   The University of North Carolina, Collaborative Studies Coordinating Center, Chapel Hill, NC, USA
,
Gretchen Marcucci
3   The University of North Carolina, Collaborative Studies Coordinating Center, Chapel Hill, NC, USA
,
Paul Sorlie
4   The National Heart, Lung, and Blood Institute, Division of Epidemiology and Clinical Applications, Bethesda, MD, USA
,
Kenneth K Wu
1   The Atherosclerosis Risk in Communities (ARIC) Study Investigators From the University of Texas Medical School, Division of Hematology-Oncology, Houston, TX, USA
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Publikationsverlauf

Received 29. November 1993

Accepted after resubmission 29. Juni 1994

Publikationsdatum:
06. Juli 2018 (online)

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Summary

Antithrombin III (AT III) is a major inhibitor of blood coagulation, and hereditary deficiency is associated with venous thrombotic disease. The Atherosclerosis Risk in Communities (ARIC) Study, a prospective study of 15,800 middle-aged men and women, measured AT III in its baseline examination. AT III levels were significantly higher in women than men, and in blacks than whites. AT III decreased with age in men but increased with age in women. In age- and race-adjusted analyses, AT III was positively associated with smoking, HDL-cholesterol, triglycerides (men only), and in women, with diabetes and lipoprotein^). AT III was negatively associated with educational level, body mass index in men, and use of female hormones in women. Most of these associations were confirmed in multivariate analysis. These correlations between AT III and other risk factors must be considered when evaluating AT III as a risk factor for venous or arterial thrombosis.

 

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