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Synthesis 2019; 51(24): 4619-4624
DOI: 10.1055/s-0039-1690207
DOI: 10.1055/s-0039-1690207
paper
Regioselective Diboron-Mediated Semireduction of Terminal Allenes
We acknowledge financial support by the National Science Foundation (CHE-1414458) and funds to purchase the Inova-400 NMR (CHE-0131124) and Agilent 6220 Accurate Mass TOF LC/MS spectrometers (CHE-0722638).Further Information
Publication History
Received: 18 August 2019
Accepted after revision: 11 September 2019
Publication Date:
10 October 2019 (online)
Abstract
A method for the regioselective reduction of the terminal double bond of 1,1-disubstituted allenes has been developed. In the presence of a palladium catalyst, tetrahydroxydiboron and stoichiometric water, allene semireduction proceeds in high yield to afford Z-alkenes selectively.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0039-1690207.
- Supporting Information
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