Late-Stage Difluoromethylation of Aliphatic Carboxylic Acids with Copper Catalysis

Wenhao Yan; Matthew Paeth; Samson Zacate; Xiaojun Zeng; Wei Liu

doi:10.1055/s-0039-1690798

Synlett, Table of Contents

Synlett 2020; 31(08): 745-749
DOI: 10.1055/s-0039-1690798

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Late-Stage Difluoromethylation of Aliphatic Carboxylic Acids with Copper Catalysis

Wenhao Yan

Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA Email: wei.liu@miamioh.edu

,

Matthew Paeth

,

Samson Zacate

,

Xiaojun Zeng

,

Wei Liu ∗

› Author Affiliations

Abstract

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Abstract

Difluoromethyl groups are of great importance to synthetic and pharmaceutical chemistry because of their unique properties that regulate molecular bioactivity. In this article, approaches towards difluoromethylation are discussed and the development of the first aliphatic decarboxylative difluoromethylation reaction is detailed. With a broad scope, the real-world utility of the protocol is demonstrated.

Key words

difluoromethylation - decarboxylative - copper catalysis - redox active ester - radicals

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References

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