One-Photon Upconversion-Like Photolysis: A New Strategy to Achieve Long-Wavelength Light-Excitable Photolysis

Wen Lv; Weiping Wang

doi:10.1055/s-0040-1707100

Synlett, Table of Contents

Synlett 2020; 31(12): 1129-1134
DOI: 10.1055/s-0040-1707100

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One-Photon Upconversion-Like Photolysis: A New Strategy to Achieve Long-Wavelength Light-Excitable Photolysis

Wen Lv

^aLaboratory of Molecular Engineering and Nanomedicine, Dr. Li Dak-Sum Research Centre, The University of Hong Kong-Karolinska Institutet Collaboration in Regenerative Medicine, The University of Hong Kong, Hong Kong, P. R. of China

,

Weiping Wang ∗

^aLaboratory of Molecular Engineering and Nanomedicine, Dr. Li Dak-Sum Research Centre, The University of Hong Kong-Karolinska Institutet Collaboration in Regenerative Medicine, The University of Hong Kong, Hong Kong, P. R. of China

^bDepartment of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, P. R. of China Email: wangwp@hku.hk

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Abstract

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Abstract

Photolysis reactions are widely utilized to release desired molecules under the control of light irradiation in the fields of photochemistry, biology, and drug delivery. In biological and medical applications, it is highly desired to increase the excitation wavelength for activating photolysis reactions, since the long-wavelength light (red or near-infrared light) has deep tissue penetration depth and low photocytotoxicity. Here, we briefly summarize current strategies of achieving long-wavelength light-excitable photolysis. We highlight our recently developed strategy of one-photon upconversion-like photolysis. Compared with the multiphoton upconversion-based photolysis, the one-photon strategy has a simpler energy transfer process and a higher energy utilization efficiency, providing a new path of activating photolysis reactions with increased excitation wavelength and photolysis quantum yield.

Key words

BODIPY - long-wavelength light excitation - photocleavable protecting groups - photocleavage - photon upconversion - red-shifted excitation - triplet-triplet annihilation - two-photon absorption

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References

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