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Synlett 2020; 31(14): 1333-1342
DOI: 10.1055/s-0040-1707143
DOI: 10.1055/s-0040-1707143
synpacts
Alkene Vicinal Difluorination: From Fluorine Gas to More Favoured Conditions
We would like to thank the Royal Society (University Research Fellowship to A.J.J.L.), EPSRC (EP/ G036764/1) and GSK for funding.Further Information
Publication History
Received: 05 May 2020
Accepted after revision: 14 May 2020
Publication Date:
18 June 2020 (online)
Abstract
Vicinal difluorinated alkanes are entities relevant to medicinal chemistry that are accessed through the difluorination of alkenes. This reaction has advanced from the use of highly reactive and unsafe reagents, which provide poor functional-group tolerance and selectivity, to the use of safer and more selective reagents that facilitate access to a broader scope of substrates. In this review article, we describe the details of these developments.
1 Introduction
2 Strategy 1: Ambiphilic Fluorine Sources
3 Strategy 2: Oxidant and Fluoride
4 Conclusions and Outlook
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