Iron-Promoted Decarboxylation of Arylacetic Acids for the Synthesis of Aromatic Nitriles with Sodium Nitrite as the Nitrogen Source

Abstract

A new and effective method was developed for the synthesis of aromatic nitriles from arylacetic acids by using NaNO₂ as the nitrogen source and Fe(OTf)₃ as the promoter at 50 °C. A series of arylacetic acids underwent this transformation to give the targeted products in yields of 51–90%. Because of the mild conditions, the reaction is compatible with a broad range of functional groups, including ester, carboxy, hydroxy, acetamido, halo, nitro, cyano, methoxy, and even highly reactive formyl groups.

Key words

aryl nitriles - nitriles - decarboxylation - sodium nitrite - iron catalysis - arylacetic acids

Publikationsverlauf

Eingereicht: 02. Juli 2020

Angenommen nach Revision: 31. August 2020

Artikel online veröffentlicht:
28. September 2020

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