Iron-Promoted Decarboxylation of Arylacetic Acids for the Synthesis of Aromatic Nitriles with Sodium Nitrite as the Nitrogen Source

Abstract

A new and effective method was developed for the synthesis of aromatic nitriles from arylacetic acids by using NaNO₂ as the nitrogen source and Fe(OTf)₃ as the promoter at 50 °C. A series of arylacetic acids underwent this transformation to give the targeted products in yields of 51–90%. Because of the mild conditions, the reaction is compatible with a broad range of functional groups, including ester, carboxy, hydroxy, acetamido, halo, nitro, cyano, methoxy, and even highly reactive formyl groups.

Key words

aryl nitriles - nitriles - decarboxylation - sodium nitrite - iron catalysis - arylacetic acids

Publication History

Received: 02 July 2020

Accepted after revision: 31 August 2020

Article published online:
28 September 2020

• References and Notes

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