Visible-Light-Mediated Photoredox Radical Cyclization Reaction with Alkyl Boronic Acids Using Molecular Oxygen as a Sole Oxidant

Abstract

Indolo[2,1-b]quinazolin-12(6H)-one derivatives are prevalent in many synthetic intermediates, pharmaceuticals, and organic materials. Herein, we developed a photoredox radical cascade cyclization reaction that uses visible light as the primary energy input to promote the reaction, leading to a series of indolo[2,1-b]quinazolin-12(6H)-one derivatives under oxygen conditions.

Key words

photoredox - radical cyclization - molecular oxygen - indolo[2,1-b]quinazolin-12(6H)-one derivatives - metal-free

Publikationsverlauf

Eingereicht: 04. Juli 2024

Angenommen nach Revision: 26. August 2024

Artikel online veröffentlicht:
07. Oktober 2024

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