Synlett 2025; 36(06): 689-694
Visible-Light-Mediated Photoredox Radical Cyclization Reaction with Alkyl Boronic Acids Using Molecular Oxygen as a Sole Oxidant
Xuanlin Qin
,
Jingting Yan
,
Li Guo
,
Jie Yao
,
Yanxue Shang
,
Yuxuan Liu
,
Xi Chen
,
Xia Wang∗
,
We thank the Hunan Province Science Foundation for Youths (2023JJ40308), the Science and Technology Innovation Program of Hunan Province (2021RC2079), the China Postdoctoral Science Foundation (2022T150075 and 2022M720541), the Scientific Research Project of the Education Department of Hunan Province (22B0212 and 23C0066), the Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project (TSBI-CIP-CXRC-038), and the National College Students Innovation and Entrepreneurship Training Program (S202210537024).
Abstract
Indolo[2,1-b]quinazolin-12(6H)-one derivatives are prevalent in many synthetic intermediates, pharmaceuticals, and organic materials. Herein, we developed a photoredox radical cascade cyclization reaction that uses visible light as the primary energy input to promote the reaction, leading to a series of indolo[2,1-b]quinazolin-12(6H)-one derivatives under oxygen conditions.
Key words
photoredox -
radical cyclization -
molecular oxygen -
indolo[2,1-b]quinazolin-12(6H)-one derivatives -
metal-free
Supporting Information
Supporting information for this article is available online at https://doi.org/10.1055/s-0043-1775135.
Supporting Information
Publication History
Received: 04 July 2024
© 2024. Thieme. All rights reserved
Georg Thieme Verlag KG
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