A Novel Method to Incorporate 2,2-Difluoroethyl Group as a Lipophilic Hydrogen-Bond Donor

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Synfacts 2024; 20(11): 1203
DOI: 10.1055/s-0043-1775154

Innovative Drug Discovery and Development

Contributor(s):

Antonia F. Stepan (Roche)

,

Seong Heon Kim (Hyundai Pharm)

2,2-difluoroethylation - hypervalent iodine salt - lipophilic H-bond donor - bioisosteres - late-stage functionalization

Article published online:
16 October 2024

Georg Thieme Verlag KG
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