Direct Synthesis of N-Substituted Phosphinecarboxamides from [TBA][P(SiCl₃)₂] and Isonitriles

Abstract

In this investigation, N-substituted phosphinecarboxamides were produced through the reaction of [TBA][P(SiCl₃)₂] with isonitriles. This method capitalizes on the flexibility of isonitriles as a source of both nitrogen and carbonyl groups, offering a novel route to the generation of PH₂-type compounds. This approach is characterized by rapid reaction times, simple procedural requirements, compatibility with a diverse array of substrates, and the conversion of [TBA][P(SiCl₃)₂] into organic phosphorus compounds. Additionally, we systematically studied the reaction mechanism of isonitrile with [TBA][P(SiCl₃)₂] through controlled experiments and density functional theory (DFT) calculations.

Key words

C–P bonds - isonitriles - phosphinecarboxamides - [TBA][P(SiCl₃)₂] - organophosphorus

Publication History

Received: 11 June 2024

Accepted after revision: 15 July 2024

Article published online:
29 August 2024

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