Rhodium(III)-Catalyzed C–C Bond Formation by Direct C–H Activation

Abstract

Transition-metal-catalyzed functionalizations of C–H bonds to construct C–C bonds represent an ideal route in the synthesis of valuable organic molecules. In particular, rhodium(III)-catalyzed C–H bond activation offers an attractive strategy due to its efficiency and step economy for direct functionalization in organic synthesis. Consequently, recent developments in this area have assured a high level of regioselectivity in C–H functionalization reactions. In this Account, we have summarized our recent achievements in the functionalizations of sp²- and sp³-C–H bonds using rhodium catalyst. The scope, limitation, and mechanism of these reactions have been described briefly.

1 Introduction

2 C–H Arylation

2.1 Aromatic C(sp²)–H Arylation

2.2 Benzylic C(sp³)–H Arylation

2.3 Olefinic C(sp²)–H Arylation

3 Olefinic C(sp²)–H Alkenylation and Alkylation

4 Olefinic C(sp²)–H Heteroarylation

5 Conclusion

Key words

rhodium(III)-catalyzed - C–H activation - arylation - alkenylation - alkylation - heteroarylation

Publication History

Received: 25 December 2024

Accepted: 09 January 2025

Article published online:
18 February 2025

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