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Synlett 1999; 1999(11): 1747-1748
DOI: 10.1055/s-1999-2929
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The Microwave Assisted Nucleophilic Substitution of 4-Hydroxy-6-methyl-2(1H)-pyridones

Dieter Heber* , Edmont V. Stoyanov
  • *Department of Pharmaceutical Chemistry, University of Kiel, Gutenbergstr. 76, D-24118 Kiel, Germany; Fax +49/04 31/8 80 11 18; E-mail: dheber@pharmazie.uni-kiel.de
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Publication Date:
31 December 1999 (online)

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The condensation of 4-hydroxy-6-methyl-2(1H)-pyridones 1 with araliphatic amino compounds 2 gives rise to the 4-alkylamino-6-methyl-2(1H)-pyridones 3. Irradiation using an ordinary domestic microwave oven provides a fast and simple method for their preparation. However, under the conditions used, aliphatic and aromatic amines gave no reaction

4-alkylamino-6-methyl-2(1H)-pyridones - microwave irradiation - condensation