PDF herunterladen
Synlett 1999; 1999(11): 1829-1831
DOI: 10.1055/s-1999-2938
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A New Method for the Synthesis of 5-Fluorouracil Prodrugs

Pascale Jolimaître* , Christiane André-Barres, Myriam Malet-Martino, Robert Martino, Isabelle Rico-Lattes
  • *Laboratoire des IMRCP (Groupe de RMN Biomédicale), UMR CNRS 5623, Université Paul Sabatier, 118 route de Narbonne, 31062 Toulouse, France; E-mail: rmnbio@ramses.ups-tlse.fr
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
31. Dezember 1999 (online)

  als PDF herunterladen  Lizenzen und Reprints Alle Artikel dieser Rubrik

Bromo-tris(dimethylamino)-phosphonium-hexafluorophosphate (BROP) is a particularly suitable reagent for synthesising some 5-fluorouracil prodrugs in a one step reaction. Several acids, especially retinoic acid, were bound to the N1 of 5-fluorouracil, with yields of about 50% after purification.

N1-retinoyl-5-fluorouracil - BROP - artificial nucleosides - prodrug