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Synlett 1999; 1999(11): 1796-1798
DOI: 10.1055/s-1999-2951
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A Facile Method for the Oxidation of Nucleoside H-Phosphonates to Phosphates with Bis(trimethylsilyl) Peroxide

Toru Kato* , Yoshihiro Hayakawa
  • *Laboratory of Bioorganic Chemistry, Graduate School of Human Informatics, Nagoya University, Chikusa, Nagoya 464-8601, Japan; Fax +81-52-7 89-56 46; E-mail: yoshi@info.human.nagoya-u.ac.jp
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Publikationsdatum:
31. Dezember 1999 (online)

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We have developed a convenient method for achieving the oxidation of nucleoside H-phosphonic acid monoesters and diesters with bis(trimethylsilyl) peroxide and N,O-bis(trimethylsilyl)acetamide in the presence of trimethylsilyl triflate as a catalyst.

H-phosphonate method - nucleoside H-phosphonate - bis(trimethylsilyl) peroxide - nucleotide synthesis