A New Guaianolide as Apoptosis Inhibitor from Chrysanthemum boreale

Jong Rok Lee; Min Suk Yang; Dae Sik Jang; Tae Joung Ha; Ki Min Park; Choong-Hwan Lee; Yung-Hee Kho; Ki Hun Park

doi:10.1055/s-2001-16477

Planta Med 2001; 67(6): 585-587
DOI: 10.1055/s-2001-16477

Letter

A New Guaianolide as Apoptosis Inhibitor from Chrysanthemum boreale

Jong Rok Lee¹ , Min Suk Yang¹ , Dae Sik Jang¹ , Tae Joung Ha¹ , Ki Min Park² , Choong-Hwan Lee³ , Yung-Hee Kho³ , Ki Hun Park^1,*

¹ Department of Agricultural Chemistry, Gyeongsang National University, Chinju, Korea
² The Research Institute of Natural Science, Gyeongsang National University, Chinju, Korea
³ Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon, Korea

Abstract

The 8-O-acetyl-3,10-dihydroxy-4(15),11(13)-guaiadien-12,6-olide, named borenolide, was isolated from Chrysanthemum boreale M. Borenolide inhibits the etoposide-induced apoptosis in U937 cell with an IC₅₀ value of 6.2 μg/ml. Structural assignment was based on NMR-spectroscopic methods and X-ray crystallographic analysis.

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Prof. Ki Hun Park

Department of Agricultural Chemistry, Gyeongsang

National University

Chinju

Korea 660-701

Email: khpark@gshp.gsnu.ac.kr

Fax: +82-55-757-0178