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Synlett 2003(10): 1463-1464
DOI: 10.1055/s-2003-40858
DOI: 10.1055/s-2003-40858
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York
Brønsted Acid-Mediated Synthesis of α-Amino Phosphonates under Solvent-Free Conditions
Weitere Informationen
Received
6 May 2003
Publikationsdatum:
24. Juli 2003 (online)
Publikationsverlauf
Publikationsdatum:
24. Juli 2003 (online)
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Abstract
Three-component reactions of aldehydes, amine, and diethyl phosphite by means of CF3COOH under the solvent-free conditions afforded α-amino phosphonates in excellent yields.
Key words
phosphonates - imines - nucleophilic additions - amine - diethyl phosphite
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References
For the synthesis of α-amino phosphonate under solvent-free conditions, see; refs. [15-17]
22Acetophenone did not react under the same reaction conditions.