Synlett 2004(1): 122-124  
DOI: 10.1055/s-2003-43353
LETTER
© Georg Thieme Verlag Stuttgart · New York

Diastereopure Preparation of α-Benzotriazolyl 1-Azacycloalka[2,1-b][1,3]-oxazines and their Application as Versatile Chiral Precursors

Xuenong Xua,b, Jun Lub, Rui Lia,b, Zongming Geb, Yanmei Dongb, Yuefei Hu*b
a Department of Chemistry, Nanjing University, Nanjing 210093, P. R. China
b Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China
Fax: +86(10)62771149; e-Mail: yfh@mail.tsinghua.edu.cn;
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Publikationsverlauf

Received 3 October 2003
Publikationsdatum:
26. November 2003 (online)

Abstract

A group of diastereopure α-benzotriazolyl 1-azacyclo­alka[2,1-b][1,3]oxazines were prepared from non-racemic Betti base and they were employed as the versatile precursors for the preparation of chiral ligands and chiral substituted azacyclics with significant advantages in the stereoselectivity.