Diastereopure Preparation of α-Benzotriazolyl 1-Azacycloalka[2,1-b][1,3]-oxazines and their Application as Versatile Chiral Precursors

Xuenong Xu; Jun Lu; Rui Li; Zongming Ge; Yanmei Dong; Yuefei Hu

doi:10.1055/s-2003-43353

LETTER

Diastereopure Preparation of α-Benzotriazolyl 1-Azacycloalka[2,1-b][1,3]-oxazines and their Application as Versatile Chiral Precursors

Xuenong Xu^a,b, Jun Lu^b, Rui Li^a,b, Zongming Ge^b, Yanmei Dong^b, Yuefei Hu*^b
^a Department of Chemistry, Nanjing University, Nanjing 210093, P. R. China
^b Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China
Fax: +86(10)62771149; e-Mail: yfh@mail.tsinghua.edu.cn;

Abstract

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Abstract

A group of diastereopure α-benzotriazolyl 1-azacycloalka[2,1-b][1,3]oxazines were prepared from non-racemic Betti base and they were employed as the versatile precursors for the preparation of chiral ligands and chiral substituted azacyclics with significant advantages in the stereoselectivity.

Key words

Betti base - chiral [1,3]oxazines - chiral ligands - chiral substituted azacyclics

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References

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