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DOI: 10.1055/s-2004-815418
Solvent-Free Benzylic Oxidations Using Urea-Hydrogen Peroxide Complex (UHP) under Microwave Irradiation
Publikationsverlauf
Publikationsdatum:
12. Januar 2004 (online)
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Abstract
Urea-hydrogen peroxide complex (UHP) has been found to be an efficient oxidizing agent for the oxidation of various alkyl benzenes/naphthalene/tetralin under microwave irradiation in solvent-free conditions.
Key words
alkylbenzenes - urea-hydrogen peroxide complex - benzylic oxidations - solvent-free conditions - microwave activation
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References
General Procedure: Substrate (1 mmol) and UHP (15 mmol) were added to a borosil beaker (50 mL). The mixture was stirred properly and then irradiated in a microwave oven for an appropriate time (Table
[1]
) at 300 W (monitored by TLC). On cooling at r.t., the product was extracted with CH2Cl2 (3 × 15 mL). The combined methylene extracts were washed with H2O and dried over anhyd Na2SO4. The product obtained after removal of the solvent under reduced pressure was crystallized from an appropriate solvent.
UHP was prepared by recrystallizing urea in 30% H2O2.
All reactions were carried out in an unmodified domestic microwave oven BPL BMO 800T having maximum output of 800 W operating at 2450 MHz.
32Paul, S.; Nanda, P.; Gupta, R. Synth. Commun., submitted.