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Synlett 2004(3): 485-488
DOI: 10.1055/s-2004-817746
DOI: 10.1055/s-2004-817746
LETTER
© Georg Thieme Verlag Stuttgart · New York
A Chemoenzymatic Approach to Optically Active 5-Hydroxy-3-oxo-carboxylates
Weitere Informationen
Received
17 December 2003
Publikationsdatum:
06. Februar 2004 (online)
Publikationsverlauf
Publikationsdatum:
06. Februar 2004 (online)
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Abstract
Enzymatic hydrolysis was applied to the preparation of certain chiral 5-hydroxy-3-oxo-carboxylates that are potential precursors for natural product synthesis via the formation of lactone derivatives and tetrahydropyran rings.
Key words
5-hydroxy-3-oxo-carboxylates - 6-substituted-4-hydroxy lactones - tetrahydropyran-4-ones - Candia Rugosa lipase (CRL) - enzymatic hydrolysis
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References
Conditions of chiral HPLC were recorded in Table [2] .