Total Synthesis of (-)-Aurisides A and B

I. Paterson; G. J. Florence; A. C. Heimann; A. C. MacKay

doi:10.1055/s-2005-865342

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Synfacts 2005(0): 0006-0006
DOI: 10.1055/s-2005-865342

Synthesis of Natural Products and Drugs

Total Synthesis of (-)-Aurisides A and B

Contributor(s): Philip Kocienski
I. Paterson*, G. J. Florence, A. C. Heimann, A. C. MacKay
Cambridge University, UK

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Publication History

Publication Date:
20 July 2005 (online)

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Significance

The first synthesis of Aurisides A and B is reported. The Aurisides are isolated from the sea hare Dolabella auricularia. They are cytotoxic towards HeLa S₃ cervical cancer cell lines with IC₅₀ values of 0.17 and 1.2 µm mL^-1, respectively.