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Synfacts 2005(0): 0011-0011  
DOI: 10.1055/s-2005-865351
Synthesis of Natural Products and Drugs
Georg Thieme Verlag Stuttgart · New York

Total Syntheses of Benzastatin E and Virantmycin

Contributor(s): Philip Kocienski
M. Ori, N. TODA, K. Takami, K. Tago, H. Kogen*
Sankyo Co., Tokyo, Japan
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Publikationsdatum:
20. Juli 2005 (online)

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Significance

The first synthesis of the natural (-)-antipode of Virantmycin is reported. Virantmycin is a potent inhibitor of RNA and DNA viruses. It is isolated from Streptomyces nitrosporeus. The related benzstatins inhibit glutamate toxicity and lipid peroxidation.