Synfacts 2005(0): 0015-0015  
DOI: 10.1055/s-2005-865353
Synthesis of Natural Products and Drugs
© Georg Thieme Verlag Stuttgart · New York

Asymmetric Synthesis of L-869,298, a Potent PDE4 Inhibitor

Contributor(s): Philip Kocienski
P. D. O’Shea*, C. Chen*, W. Chen, P. Dageneau, L. F. Frey, E. J. J. Grabowski, K. M. Marcantonio, R. A. Reamer, L. Tan, R. D. Tillyer, A. Roy, X. Wang, D. Zhao
Merck Frosst Centre for Therapeutic Research, Quebec, Canada; Merck Research Laboratories, Rahway, USA
Further Information

Publication History

Publication Date:
20 July 2005 (online)

Significance

The target molecule inhibits phosphodiesterase-4 (PDE4), an enzyme that hydrolyzes cAMP. It is a potential drug for the treatment of asthma and chronic obstructive pulmonary disease.