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Synfacts 2005(0): 0077-0077  
DOI: 10.1055/s-2005-865381
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York

Stereocontrolled SPOS of an Indoline-Alkaloid-like Library

Contributor(s): Yasuhiro Uozumi, Masahiro Kimura
Z. Gan, P. T. Reddy, S. Quevillon, S. Couve-Bonnaire, P. Arya*
National Research Council of Canada, University of Ottawa, Canada
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Publication History

Publication Date:
20 July 2005 (online)

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Significance

A 90-membered library of indoline-alkaloid-like polycyclic compounds was synthesized through stereoselective hetero-Michael reactions with nitrogen nucleophiles as the key step. The seven synthetic steps on the solid-support were carried out under very mild conditions to give the library members in high yields (80-85%).