Synlett 2005(10): 1633-1635  
DOI: 10.1055/s-2005-869859
LETTER
© Georg Thieme Verlag Stuttgart · New York

A Novel Efficient Three-Component One-Pot Synthesis of 1,3-Diazabicyclo[3.1.0]hex-3-ene System under Microwave Irradiation

Francesco Risitano*, Giovanni Grassi, Francesco Foti, Sonia Moraci
Dipartimento di Chimica Organica e Biologica, Università, Vill. S. Agata, 98166 Messina, Italy
Fax: +39(090)393897; e-Mail: frisitan@isengard.unime.it;
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Publication History

Received 15 April 2005
Publication Date:
07 June 2005 (online)

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Abstract

Bridgehead aziridines 3 were synthesized in high yields and excellent diastereocontrol by a three-component reaction of an aldehyde, phenacyl chloride and ammonium acetate in acetic acid using microwave irradiation.