A Polymeric FeCl₃ Catalyst for Deprotection of Acetonides

Significance

Highly chemoselective deprotection of diacetone sugars bearing various functional groups was achieved at room temperature for 30 minutes using poly(4-vinylpyridine)-supported ferric chloride (5 mol%) to give the corresponding terminal diols 2 in 87-94% yields (15 substrates). This method was found to be of good functional compatibility with acid-sensitive groups such as TBDMS, THP, OBn, OBz, and OAc. The polymeric catalyst was readily recycled without lenching of ferric chloride.