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Synfacts 2005(0): 0046-0046
DOI: 10.1055/s-2005-869911
DOI: 10.1055/s-2005-869911
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Selective 1,3-Isomerization of Allylic Alcohols via Rhenium Oxo Catalysis
C. Morrill, R. H. Grubbs*
California Institute of Technology, Pasadena, USA
Further Information
Publication History
Publication Date:
20 July 2005 (online)
Significance
A protocol featuring mild conditions, short reaction times and low catalyst loading has been developed for the 1,3-isomerization of allylic alcohols using a rhenium oxo catalyst. Enantioenriched starting materials undergo isomerization with only a small loss of optical purity.