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Synfacts 2005(0): 0035-0035
DOI: 10.1055/s-2005-869912
DOI: 10.1055/s-2005-869912
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Ir-Catalyzed Allylic Amination and Etherification
C. Welter, A. Dahnz, B. Brunner, S. Streiff, P. Dübon, G. Helmchen*
Universität Heidelberg, Germany
Further Information
Publication History
Publication Date:
20 July 2005 (online)
Significance
This system allows for highly stereoselective intramolecular allylic aminations and etherifications as well as intermolecular allylic amination followed by intramolecular cyclization (shown). Low catalyst loading (2 mol%), and fast reaction times make this a suitable system for the synthesis of various ring sized N-heterocycles.