Enantioselective Friedel-Crafts Alkylations by Strained Chiral Silacycle

S. Shirakawa; R. Berger; J. L. Leighton

doi:10.1055/s-2005-869914

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Synfacts 2005(0): 0048-0048
DOI: 10.1055/s-2005-869914

Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions

Enantioselective Friedel-Crafts Alkylations by Strained Chiral Silacycle

Contributor(s): Hisashi Yamamoto, Matthew Boxer
S. Shirakawa, R. Berger, J. L. Leighton*
Columbia University, New York, USA

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Publication History

Publication Date:
20 July 2005 (online)

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Significance

A chiral silicon Lewis acid has been utilized for the enantioselective Friedel-Crafts alkylation. The strained silacyle is effective at promoting the reaction for electron-rich aromatic systems under mild conditions.