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Synfacts 2005(0): 0058-0058  
DOI: 10.1055/s-2005-869918
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Direct Dinuclear Zinc Aldol Addition

Contributor(s): Hisashi Yamamoto, Matthew Boxer
B. M. Trost*, M. U. Frederiksen, J. P. N. Papillon, P. E. Harrington, S. Shin, B. T. Shireman
Stanford University, USA
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Publication History

Publication Date:
20 July 2005 (online)

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Significance

This paper utilizes the author’s previously reported direct aldol addition in the formal asymmetric syntheses of fostriecin. The use of alkynyl methyl ketones as an enolate precursor was recently reported by this group and has now been used in the studies of natural product synthesis.