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Synfacts 2005(0): 0063-0063  
DOI: 10.1055/s-2005-869921
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

New Synthesis of Heterocycles via Azatitanacyclopentadiene Intermediates

Contributor(s): Paul Knochel, Andrei Gavryushin
D. Suzuki, Y. Nobe, Y. Watai, R. Tanaka, Y. Takayama, F. Sato*, H. Urabe*
Tokyo Institute of Technology, Japan
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Publikationsdatum:
20. Juli 2005 (online)

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Significance

The reaction between acetylenes and nitriles in the presence of titanium(II) alkoxides represents an easy route for the preparation of various polyfunctional heterocycles. A number of substituted pyridines, pyrroles and furans, bearing a variety of substituents, were prepared under mild conditions in good yields. A very operationally simple procedure was developed.