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Synfacts 2005(0): 0064-0064  
DOI: 10.1055/s-2005-869922
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Carboxylation and Esterification of Functionalized Arylcopper Reagents

Contributor(s): Paul Knochel, Andrei Gavryushin
G. Ebert*, W. Luda, R. Kosakowski, B. Ma, L. Dong, K. Cummings, M. Phelps, A. Mostafa, J. Luo
State University of New York College at Buffalo, USA
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Publikationsdatum:
20. Juli 2005 (online)

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Significance

The synthesis of substituted benzoate esters from aryl iodides was performed using the insertion of active copper metal, generated from CuI-PEt3 complex and lithium naphthalenide, followed by the carboxylation with CO2. The method allows preparing a number of aryl benzoates, bearing functional groups which are not compatible with standard organomagnesium chemistry.