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Synfacts 2005(0): 0070-0070  
DOI: 10.1055/s-2005-869923
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Hydroboration with Pyridine Borane

Contributor(s): Paul Knochel, Andrei Gavryushin
J. M. Clay, E. Vedejs*
University of Michigan, USA
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Publikationsdatum:
20. Juli 2005 (online)

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Significance

A stable available pyridine-borane complex after the reaction with iodine gives a selective hydroborating agent, active at room temperature. Acetylenes can be transformed into ketones after oxidation. Mono-, di- and trisubstitut­-ed alkenes can be readily hydroborated leading to mono-adducts at room temperature. Functional groups like esters, amines and amides are tolerated.