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Synfacts 2005(0): 0066-0066  
DOI: 10.1055/s-2005-869925
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Diastereoselective Rh-Catalyzed Addition of Arylboron Compounds to Sulfinimines

Contributor(s): Paul Knochel, Andrei Gavryushin
Y. Bolshan, R. A. Batey*
University of Toronto, Canada
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Publikationsverlauf

Publikationsdatum:
20. Juli 2005 (online)

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Significance

The synthesis of chiral benzylic amines is an important task, since these compounds often possess biologic activity. Usual addition of an organometallic reagent to imines is limited by various factors including functional group compatibility and use of highly sensitive reagents. This protocol offers very mild reaction conditions and is advantageous due to the stability and availability of the reactants.