Modular Catalysts for the Enantioselective Allylation of Aldehydes

J.-Y. Lee; J. J. Miller; S. S. Hamilton; M. S. Sigman

doi:10.1055/s-2005-869927

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Synfacts 2005(0): 0065-0065
DOI: 10.1055/s-2005-869927

Metal-Mediated Synthesis

Modular Catalysts for the Enantioselective Allylation of Aldehydes

Contributor(s): Paul Knochel, Andrei Gavryushin
J.-Y. Lee, J. J. Miller, S. S. Hamilton, M. S. Sigman*
University of Utah, USA

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Publikationsdatum:
20. Juli 2005 (online)

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Significance

The formerly developed Mn-Cr(II)-mediated allylation of aldehydes for the first time has been performed in an enantioselective variant using a set of modular amino acid-derived ligands. Enantioselectivities of up to 95% were achieved after screening of different catalyst diastereomers.