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Synfacts 2005(0): 0073-0073
DOI: 10.1055/s-2005-869930
DOI: 10.1055/s-2005-869930
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York
A General Process for Synthesis of Enantiopure Sulfinates and Sulfoxides
B. Z. Lu*, F. Jin, Y. Zhang, X. Wu, S. A. Wald, C. H. Senanayake*
Process R&D, Sepracor, Inc., USA
Further Information
Publication History
Publication Date:
20 July 2005 (online)
Significance
Among various methods, developed for the synthesis of enantiopure sulfoxides, the use of naturally occurring quinine as a chiral auxiliary has a lot of advantages: all the reagents are easily available, cheap, the one-pot procedure is very simple to perform and the auxiliary can be readily recovered. The procedure gives in all reported cases practically enantiopure products.