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Synfacts 2005(0): 0071-0071  
DOI: 10.1055/s-2005-869932
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Ni-Catalyzed Alkylative Dimerization of Vinyl Grignard Reagents Using Alkyl Fluorides

Contributor(s): Paul Knochel, Andrei Gavryushin
J. Terao, H. Watabe, N. Kambe*
Osaka University, Japan
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Publication History

Publication Date:
20 July 2005 (online)

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Significance

For this reaction, alkyl fluorides were found superior as alkylating agents than alkyl chlorides and iodides. Vinylmagnesium chloride serves here as a useful C4-synthon for the construction of a branched carbon skeleton, potentially applicable in various synthetic schemes.