Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2005(0): 0059-0059
DOI: 10.1055/s-2005-869947
DOI: 10.1055/s-2005-869947
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Chiral Ferrocenyl Phosphine-Triazines as Ligands for Asymmetric Allylic Substitution
X.-P. Hu, H.-L. Chen, Z. Zheng*
Dalian Institute of Chemical Physics, P. R. China
Further Information
Publication History
Publication Date:
20 July 2005 (online)
Significance
Asymmetric allylic alkylations have been exhaustively studied, and excellent enantioselectivities have been demonstrated in numerous cases. Ferrocenyl-based P,N-ligands have recently received attention, with the incorporation of N-heterocycles believed to influence selectivity. The pendant triazine was found to increase enantioselectivity, with better selectivity than cases with less N content. Allylic substitution with malonates (α-substituted and unsubstituted) and benzylamine were demonstrated, displaying excellent yield and selectivity with malonates, and good yield and selectivity with amination.