Chiral Ferrocenyl Phosphine-Triazines as Ligands for Asymmetric Allylic Substitution

Significance

Asymmetric allylic alkylations have been exhaustively studied, and excellent enantio­selectivities have been demonstrated in numerous cases. Ferrocenyl-based P,N-ligands have recently received attention, with the incorporation of N-heterocycles believed to influence selectivity. The pendant triazine was found to increase enantio­selectivity, with better selectivity than cases with less N content. Allylic substitution with malonates (α-substituted and unsubstituted) and benzyl­amine were demonstrated, displaying excellent yield and selectivity with malonates, and good yield and selectivity with amination.