Metal Chloride-Promoted Aldol Reaction of α-Dimethylsilylesters with Aldehydes, Ketones, and α-Enones

Abstract

In the presence of a catalytic amount of LiCl, α-dimethylsilylesters (α-DMS-esters) 1 smoothly reacted with various aldehydes at 30 °C to give aldols in good to high yields. On the other hand, the aldol reaction with ketones was effectively promoted by MgCl₂ rather than by LiCl. α-Enones also underwent the metal chloride-promoted addition of 1 at the carbonyl carbon or β-carbon.

Key words

aldehydes - aldol reactions - ketones - Michael additions - α-silylesters

References

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• 11c

  Typical Procedure for the Preparation of α-DMS-esters 1
  Under N₂ atmosphere, n-BuLi (1.61 M in hexane, 62 mL, 100 mmol) was added to a solution of i-Pr₂NH (14 mL, 100 mmol) in THF (100 mL) over 5 min at 0 °C. After 10 min, the mixture was cooled to -78 °C. Then, EtOAc (9.3 mL, 95 mmol) was added to the solution of LDA over 5 min. After 2 h, the reaction mixture was treated with chlorodimethyl-silane (12.2 mL, 110 mmol) and gradually warmed to r.t. over 12 h. The resultant mixture was diluted with dry pentane (50 mL) and filtered through Celite^®. After evaporation of the filtrate, the residual oil was diluted with dry pentane (50 mL) again, filtered through Celite^®, and evaporated. Purification of the crude product by distillation gave 1a (9.2 g, 63 mmol) in 66% yield.
  Compound 1a: bp 58-60 °C (180 Torr). IR (neat): 1669 (C=O), 1253, 1205 cm^-1. ¹H NMR (CDCl₃): δ = 0.20 (d, J = 3.6 Hz, 6 H), 1.23 (t, J = 6.9 Hz, 3 H), 1.96 (d, J = 3.3 Hz, 2 H), 4.06 (sept, d, J = 3.6, 3.3 Hz, 1 H), 4.10 (q, J = 6.9 Hz, 2 H). ¹³C NMR (CDCl₃): δ = -4.36 (CH₃ × 2), 14.09 (CH₃), 24.08 (CH₂), 59.91 (CH₂), 172.54 (C). Anal. Calcd for C₆H₁₄O₂Si (%): C, 49.53; H, 9.69. Found: C, 49.27; H, 9.65.

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12

General Procedure for the Aldol Reaction of 1 with Aldehydes 2
Under the atmosphere, dry LiCl (5.5 mg, 0.13 mmol) was added to a two-necked, round-bottomed flask (10 mL), which was connected with a nitrogen balloon. After introduction of nitrogen, DMF (1.0 mL) was added to the flask. The mixture was warmed to 30 °C under stirring. After 10 min, 2 (0.50 mmol) and 1 (0.60 mmol) were added to the mixture. After being stirred for 5 h, the reaction mixture was treated with 2 M aq HCl (1 mL) for 5 min and neutralized with sat. aq NaHCO₃. The aqueous mixture was extracted with EtOAc (3 × 10 mL). The extract was dried over Na₂SO₄ and evaporated. The crude product was purified by silica gel column chromatography.

19

As shown in Table [3] , the reaction of 1a with 8a proceeded efficiently irrespective of the metal chloride used. This observation may be due to higher coordinating ability (Lewis basicity) of α-enones, which allows carbonyl activation even with less Lewis acidic metal ions. For the coordinating ability of α-enones, see ref. 17a.