Total Synthesis of Tirandalydigin

Y. Iwata; N. Maekawara; K. Tanino; M. Miyashita

doi:10.1055/s-2005-872151

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Synfacts 2005(1): 0096-0096
DOI: 10.1055/s-2005-872151

Synthesis of Natural Products and Potential Drugs

Total Synthesis of Tirandalydigin

Contributor(s): Philip Kocienski
Y. Iwata, N. Maekawara, K. Tanino, M. Miyashita*
Hokkaido University, Sapporo, Japan

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Publication History

Publication Date:
21 September 2005 (online)

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Significance

The target compound inhibits bacterial DNA-directed RNA polymerase. Major accomplishments in the synthesis were (a) the construction of the acid-labile vinyl epoxide and (b) the construction of the tetramic acid.